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The role of cholelithiasis risk factors in stone types in cholelithiasis patients at Universitas Sumatera Utara Hospital


Introduction: Cholelithiasis is the most common disease in the biliary tract. Several risk factors have been known as risk factors of cholelithiasis, such as obesity and female gender. Meanwhile, only few studies evaluate correlation between clinical characteristics and stone type in cholelithiasis. The study aims to evaluate correlation between clinical characteristics and stone type in cholelithiasis patients at Universitas Sumatera Utara Hospital.

Method: The study design was cross sectional. The sample of this study was 35 people with cholelithiasis patients who underwent cholecystectomy either by open or laparoscopic cholecystectomy at Universitas Sumatera Utara Hospital. Gallstones will be examined by a laboratory. Risk factors assessed were age, gender, body mass index, hemoglobin bilirubin, cholesterol levels. Data analysis will use the Kruskal Wallis test.

Result: From 35 study samples was found the most types of stones were mixed stones with 17 (48.6%). Based on the Kruskal Wallis test found a significant relationship between the type of stone with gender, body mass index, total bilirubin, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).

Conclusion: Factors related to the type of cholelithiasis stone are gender, body mass index, bilirubin levels, total cholesterol levels, HDL-C, and LDL-C.


  1. William NS, O’Connel PR, Mc Caskie AW. The Gallbladder and Bile Duct. In: Bailey & Love’s Short Practice of Surgery 27th Edition. CRC Press. 2018;12:1188- 1199.
  2. Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology. 2009;36:376–386.
  3. Stinton LM, Shaffer EA. Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer. Gut Liver. 2012;6(2):172-187.
  4. Abbass S, Ahmad I, Gyedu A, Adae-Aboagye K, Badu-Peprah A. Prevalence of Cholelithiasis among persons undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Africa Health Science. 2015;15: 246-252.
  5. Bhatti AY, Waqar AB, Zia SA, Hussain N, Zulfiqar T. A Cross Sectional Study on The Risk Of Gallbladder Stone. International Journal of Research in Medical Science. 2016;4(11):5041-5046.
  6. Dhamnetiya D, Goel MK, Dhiman BR, Pathania OP. Risk Factor Associated with Gallstone Disease. Indian Journal of Community Health. 2018;30(2):113-18.
  7. Park Y, Kim D, Lee JS, Jeong YK, Lee KG, Choi D. Association Between Diet and Gallstone of Cholesterol and Pigmen Among Patients ith Cholecystectomy: A Case –Control Study in Korea. J Health Popul Nutr. 2017;36:39-45.
  8. Kereh DS, Lampus H, Sapan H, Loho LL. Correlation between stone type and gallbladder histology in person with cholelithiasis. Biomedical Journal. 2017;7: 41-47.
  9. Qiao T, Ma RH, Luo XB, Yang LQ, Luo ZL, Zheng PM. The systematic classification of gallbladder stones. PLoS One. 2013;8(10):e74887.
  10. Goktas SB, Manukyan M, Sellmen M. Evaluation of Factor Affecting The Type of Gallstone. Indian Journal Surgery. 2015;78(1):20-26.
  11. Völzke H, Baumeister SE, Alte D, et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005;71:97– 105.
  12. Cirillo DJ, Wallace RB, Rodabough RJ. Effect of estrogen therapy on gallbladder disease. JAMA. 2005;293:330–339.
  13. Kim HS, Cheo SK, Kim CS, Park JS. Big Data and Analysis of Risk Factors for Gallbladder Disease in the Young Generation of Korea. Plos One. 2019;14(2): e0211480.
  14. Sharma R, Sachan1 SG, dan Sharma SR. Preponderance of Gallstone in Female. World Journal of Pharmacy and Pharmaceutical Sciences. 2013;2(6):5871- 5877.
  15. Shabanzadeh DM, Sørensen LT, Jørgensen T. Determinants for gallstone formation - a new data cohort study and a systematic review with meta-analysis. Scand J Gastroenterol. 2016;51(10):1239-48.
  16. Moghaddam AA, Khorram A, Bonjar MM, Mohammadi M, Ansari H. The Prevalence and Risk Factors of Gallstone Among Adults in South-East of Iran: A Population-Based Study. Global Journal of health Science. 2016;8(4):60-67.
  17. Van Erpecum KJ. Pathogenesis of cholesterol and pigment gallstones: An update. Clin Res Hepatol Gas. 2011;35(4):281–7.
  18. Chandran PNK, Kuchhal T. An Extended Chemical Analysis of Gallstone. Indian Journal of Clinical Biochemistry. 2007;22(2):145-150.

How to Cite

Siregar, D. R., Muhar, A. M., & Pohan, D. P. (2021). The role of cholelithiasis risk factors in stone types in cholelithiasis patients at Universitas Sumatera Utara Hospital. Bali Medical Journal, 10(1), 63–65.




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Denny Rifsal Siregar
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Adi Muradi Muhar
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Doddy Prabisma Pohan
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