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Spontaneous conversion to sinus rhythm in atrial fibrillation after dual antiplatelet and anticoagulant therapy in patients with unstable angina

Abstract

Introduction: Atrial fibrillation (AF) is a common arrhythmia and often becomes persistent with a high risk of thromboembolism event. Spontaneous conversion to sinus rhythm can occur in 50% of cases with new-onset AF. In this case report we report the spontaneous conversion of AF to sinus rhythm in patients with Unstable Angina without any thromboembolic complications.

Case description: A 65-year-old man with unstable angina pectoris (UA) with new-onset atrial fibrillation normal ventricular rate (AF-NVR) came to the Emergency Department Bali Mandara General Hospital. Patients have a history of uncontrolled hypertension and active smokers. Standard management of UA using dual antiplatelet, nitrates, and anticoagulants was given to this patient. There were no anti-arrhythmia drugs given to seek for AF cardioversion. Within 6 hours after initial therapy, spontaneous conversion of AF to sinus rhythm occurs. The patient was treated for five days in a stable condition without thromboembolic complications. Long-term anticoagulants were not given to patients because the CHA2DS2-Vasc score is less than two indicating a low risk of thromboembolism.

Conclusion: New-onset AF has the chance of spontaneous conversion to sinus rhythm within 48 hours, proper management of the trigger factors of AF and optimal rate control are determinants of prognosis. Provision of long-term anticoagulants must be based on the CHA2DS2-Vasc score.

References

  1. Gregory YH, Apostolaksis S. Atrial fibrillation (acute onset). Clinical Evidence. 2014;11:210-253.
  2. Krichol P, Benussi S, Koteca D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, et al. 2016 ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS European Heart Journal. 2016;37:1893-2962.
  3. Maggioni AP. Acute coronary syndrome in patients with atrial fibrillation, what is the benefit/risk profile of triple antithrombotic therapy. Circulation. 2012;126:1176-1178.
  4. Farrar WS, Johnson LF, Meachler CJ, Dusek JA. Spontaneous normal sinus rhythm conversion using intergrative medicine in atrial fibrillation. Global Advances in Health and Medicine. 2012;1(2):1-4.
  5. Alasady M, Walter APA, Darryl PL, Han SL, Hany AS. Coronary artery disease affecting the atrial branches is an independent determinant of atrial fibrillation after myocardial infarction. Heart Rhythm. 2011;8(7):955–60.
  6. Mohamed MO, Kirchhof P, Vidovich M, Savage M, Rashid M, Kwok CS, et al. Effect of concomitant atrial fibrillation on in-hospital outcomes of non-ST-elevation acute coronary syndrome-related hospitalizations in he United States. Am J Cardiol. 2019;124(4):465-475.
  7. Kea B, Alligood T, Manning V, Raitt M. A review of the relationship of atrial fibrillation and acute coronary syndrome. Curr Emerg Hosp Med Rep. 2016;4(3):107-118.
  8. Michniewicz E, Mlodawska E, Lopatowska P, Kazberuk AT, Malyszko J. patients with atrial fibrillation and coronary artery disease-double trouble. Advance in Medical Sciences. 2018;63:30-35.
  9. Handoyo V, Pertiwi GAR, Prabawa IPY, Manuaba IBAP, Bhargah A, Budiana IPG. Management of ST-elevation myocardial infarction in the setting of anterior epistaxis: focused on antiplatelet and antithrombotic therapies. International Medical Case Reports Journal. 2019;12:33-38.
  10. Yasuda S, Kaikita K, Akao M, Ako J, Matba T, Nakamura M, Miyauchi K, et al. Antithrombotic therapy for atrial fibrillation with stable coronary artery disease. The New England Journal of Medicine. 2019; 381(12):1103-1113.
  11. Heldal M, Atar D. Pharmacological conversion of recent-onset atrial fibrillation: a systemtic review. Scandinavian Cardiovascular Journal. 2013;47:2-10.
  12. Rubenstein JC, Cinquergrani MP, Wright J. Atrial fibrillation in acute coronary syndrome. Journal of Atrial Fibrillation. 2012;(1):35-42.
  13. Yan L, Jiang T, Yang X, Xu M. Spontaneous conversion of atrial firbrillation caused by severe hyperkalemia. Medicine. 2015;97:15(e0442).
  14. Sharma M, Mascarenhas DAN, Kantharia B. Conversion of atrial fibrillation to sinus rhythm during coronary intervention: complex interplay of arrhythmic and ischemic substrate. Cardiol Res. 2018;9(1):72-74.
  15. Danias PG, Caulfield TA, Weigner MJ, Silverman DI, Manning WJ. Likelihood of spontaneous conversion of atrial fibrillation to sinus rhythm. JACC. 1998;31(3):588-92.
  16. Choundhary MB, Holmqvist F, Carlson J, Nilsson HJ, Roijer A, Platonov PG. Low atrial fibrillatory rate is associated with spontaneous conversion of recent-onset atrial fibrillation. Eurospace. 2013;15:1445-1452.

How to Cite

Bhargah, A., Jayantika, I. G. A. B. K., Prabawa, I. P. Y., & Manuaba, I. B. P. (2020). Spontaneous conversion to sinus rhythm in atrial fibrillation after dual antiplatelet and anticoagulant therapy in patients with unstable angina. Bali Medical Journal, 9(3), 664–667. https://doi.org/10.15562/bmj.v%vi%i.2011

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Agha Bhargah
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I Gusti Agung Bagus Krisna Jayantika
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I Putu Yuda Prabawa
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Ida Bagus Putra Manuaba
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