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Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis



Abstract

Background: Sudden sensorineural hearing loss (SSNHL) is a common otologic disease characterized by a loss of hearing greater than 30 dB in three consecutive frequen­cies which occurs in less than 72 hours. Objective: To investigate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on sudden sensorineural hearing loss (SSNHL). Search strategy: A PubMed, Science Direct, Scopus, OVID, EMBASE and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All case-control studies, which have been investigated the relationship of NLR and PLR with the occurrence of SSNHL were included in our meta-analysis. Results: A total of 5 case-control studies were included in the study. All 5 studies have been reported NLR of patients and control groups (611 patients and 804 controls). Our analysis showed that the mean NLR of patients is 1.12 (0.82-1.43) unit higher than that of controls with 95% CI which is statistically significant. Also, 3 studies have been reported PLR of patients and control groups (512 patients and 705 controls). Our analysis showed that the mean PLR of patients is 0.57 (0.08-1.05) unit higher than that of controls with 95% CI which is statistically significant too. Conclusions: This meta-analysis confirmed the relationship of NLR and PLR with SSNHL. Therefore, these parameters can be considered as new markers in diagnosis of SSNHL. 

Keywords: Sudden sensorineural hearing loss neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio

How to Cite

Bahrami, M. A., Ansari, A., Chaman-Ara, K., Bahrami, E., Bahrami, S., Bahrami, M. N., Barati, O., Moosazadeh, M., & guzhan Kum, R. O. (2016). Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Novel Markers for Diagnosis of Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis. Bali Medical Journal, 5(2), 197–201. https://doi.org/10.15562/bmj.v5i2.198
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Mohammad Amin Bahrami
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Abdollah Ansari
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Kefayat Chaman-Ara
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Elham Bahrami
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Sima Bahrami
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Mohammad Nabi Bahrami
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Omid Barati
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Mahmood Moosazadeh
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Rauf O˘ guzhan Kum
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