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Assessment of lipid profile among patients with seborrheic dermatitis



Abstract

Background: Although the complicated interplay of Malassezia, keratinocytes and the immune response against a modified lipid composition in the skin have a vital role in the pathogenesis of Seborrheic Dermatitis (SD), the pathophysiology itself is still inadequately understood.  The association of SD with metabolic syndrome like dyslipidemia can be explained by inflammation in both conditions' pathogenesis. The present study was aimed at evaluating the relationship between the lipid profile abnormality and the SD. 

Methods: A prospective cross-sectional study was conducted in the Dermatology teaching center in Sulaimani, Iraq, from 1/9/2019 to 1/3/2020. This study used a structured data collection format comprised of items concentrating on socio-demographic characteristics, duration of the disease, level of SD, the severity of SD, and lipid profile. The data were analyzed by STATA 14 statistical software and summarized in tables and figures. The Chi-square test was done to detect the association between categorical variables. P-value <0.05 was significant.

Results: A total of 100 patients with seborrheic dermatitis with the average age of patients was 37.5 ±13.06 years, and 61 were females. The mean fasting total cholesterol (219.72 mg/dl vs.114.83 mg/dl), LDL-C (123.92 mg/dl vs. 85.08 mg/dl) and triglycerides (170.38 mg/dl vs.102.17 mg/dl) levels were higher for the high-level cases than the normal level cases.  The HDL-C level (31.06 mg/dl vs. 38.94 mg/dl) of the high-level patients was lower than normal patients. Age, total cholesterol level, LDL-C, triglycerides, and HDL-C had a statistically significant association with the disease's level and severity. The duration of the disease had a statistically significant association with only the level of disease.

Conclusion: Lipid profile has a statistically significant association with the level and severity of SD. Finally, we recommend a large observational study to depict the causal relationship between serum lipid abnormality and SD.

Keywords: Lipid Profile Seborrheic Dermatitis Sulaimani Kurdistan Region-Iraq

References

  1. Tucker D, Masood S. Seborrheic Dermatitis. StatPearls [Internet]: Stat Pearls Publishing. 2019.
  2. McGinley T, Cornejo K, Lambert P. Seborrheic Dermatitis. Common Dermatologic Conditions in Primary Care: Springer; 2019:87-97.
  3. De Avelar Breunig J, Couto MOR. Seborrheic Dermatitis. Dermatology in Public Health Environments: Springer; 2018:429-47.
  4. Zander N, Sommer R, Schäfer I, Reinert R, Kirsten N, Zyriax BC, et al. Epidemiology of seborrheic dermatitis. Bri J Dermatol. 2019;181(4):e92-e.
  5. Asz-Sigall D, Tosti A. Seborrheic Dermatitis. Hair and Scalp Treatments: Springer; 2020:161-76.
  6. Kellen R, Silverberg N. Adolescent Seborrheic Dermatitis. Harper's Textbook of Pediatric Dermatology. 2019:279-86.
  7. Mameri ACA, Carneiro S, Mameri LMA, Telles da Cunha JM, Ramos-E-Silva M. History of seborrheic dermatitis: conceptual and clinico-pathologic evolution. Skin Med. 2017;15(3):187-94.
  8. Paulino LC. New perspectives on dandruff and seborrheic dermatitis: lessons we learned from bacterial and fungal skin microbiota. Eur J Dermatol. 2017;27(1):4-7.
  9. Li X, He C, Chen Z, Zhou C, Gan Y, Jia Y. A review of the role of sebum in the mechanism of acne pathogenesis. J Cosm Dermatol. 2017;16(2):168-73.
  10. Zhou S-S, Li D, Zhou Y-M, Cao J-M. The skin function: a factor of anti-metabolic syndrome. Diabetol Metab Syndr. 2012;4(1):15.
  11. Elias PM. Lipid abnormalities and lipid-based repair strategies in atopic dermatitis. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids. 2014;1841(3):323-30.
  12. Imamoglu B, Hayta SB, Guner R, Akyol M, Ozcelik S. Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. Arch Med Sci Atherosclerotic Dise. 2016;1(1): e158.
  13. Sobhan M, Rabiei MAS, Amerifar M. Correlation Between Lipid Profile and Acne Vulgaris. Clin Cosmet Investig Dermatol. 2020;13:67.
  14. Utami OC, Kurniawati Y, Diba S, Saleh MI, editors. Correlation between serum lipid profile and acne vulgaris severity. J Physics: Conference Series; 2019: IOP Publishing.
  15. Berdyshev E, Goleva E, Bronova I, Dyjack N, Rios C, Jung J, et al. Lipid abnormalities in atopic skin are driven by type 2 cytokines. JCI insight. 2018;3(4).
  16. Gisondi P, Fostini AC, Fossà I, Girolomoni G, Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol. 2018;36(1):21-8.
  17. Borda LJ, Perper M, Keri JE. Treatment of seborrheic dermatitis: a comprehensive review. J Dermatol Treat. 2019;30(2):158-69.
  18. Enos C, Patel T, Patel S, França K. Seborrheic dermatitis. Stress and Skin Disorders: Springer; 2017:165-9.
  19. Gupta AK, Versteeg SG. Topical treatment of facial seborrheic dermatitis: a systematic review. Am J Clin Dermatol. 2017;18(2):193-213.
  20. Elgash M, Dlova N, Ogunleye T, Taylor SC. Seborrheic Dermatitis in Skin of Color: Clinical Considerations. J Drugs Dermatol: JDD. 2019;18(1):24-7.
  21. Sanders M, Pardo L, Franco O, Ginger R, Nijsten T. Prevalence and determinants of seborrhoeic dermatitis in a middleâ€aged and elderly population: the Rotterdam Study. Bri J Dermatol. 2018;178(1):148-53.
  22. Misitzis A, Cunha PR, Kroumpouzos G. Skin disease related to metabolic syndrome in women. Int J Women's Dermatol. 2019;5(4):205-12.
  23. Toruan T, Nopriyati, Theodorus, Sari Y. The Relationship between Serum Lipid Profile and Sebum Secretion in Seborrheic Dermatitis Patients. Int J Health Sci Res. 2017;7(4):138-43.
  24. Agarwal K, Das S. Metabolic syndrome–the underbelly of Dermatology. Gulf J Dermatol Venereol. 2019;26(2):1-10.
  25. Stefanadi EC, Dimitrakakis G, Antoniou C-K, Challoumas D, Punjabi N, Dimitrakaki IA, et al. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for highrisk patients. Diabetol Metab Syndr. 2018;10(1):9.
  26. Dumas SN, Ntambi JM. A Discussion on the Relationship between Skin Lipid Metabolism and Whole-Body Glucose and Lipid Metabolism: Systematic Review. J Cell Sig. 2018;3(3).
  27. Tanmay Padhi G. Metabolic syndrome and skin: psoriasis and beyond. Ind J Dermatol. 2013;58(4):299.
  28. Svacina S. Metabolic syndrome and skin diseases. Cas Lek Cesky. 2008;147(6):307-10.
  29. Wikramanayake TC, Borda LJ, Miteva M, Paus R. Seborrheic dermatitis—Looking beyond Malassezia. Exp Dermatol. 2019;28(9):991-1001.

How to Cite

Abdulrahman, B. B., Elethawi, A. M. D., & Abdullah, H. M. (2020). Assessment of lipid profile among patients with seborrheic dermatitis. Bali Medical Journal, 9(3), 952–958. https://doi.org/10.15562/bmj.v9i3.1959
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Barez Burhan Abdulrahman
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Ali Muzan Dhahir Elethawi
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Hadi Mohammed Abdullah
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