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Factors affecting the mini-mental state examination (MMSE) score in the epilepsy patients in Aceh, Indonesia


Background: Epilepsy patients in developing countries is quite high. A person can have epilepsy within a certain time limit, but also not a few people who survive with this condition for life. This situation will affect cognitive function. Cognitive function impairment in epilepsy patients can be triggered by various factors related to aetiology, clinical, and others. Therefore, we tried to find the factors that influence the cognitive function in epilepsy patients.

Methods: This study was an observational analytic study with a cross-sectional design. The study was conducted using primary data obtained from direct interviews and MMSE examination and secondary data obtained from medical records to confirm the diagnosis of epilepsy. Samples were collected based on the diagnosis of neurologist in the patient's medical record at the Regional General Hospital Dr. Zainoel Abidin Banda Aceh from October to December 2019. This study involved thirty-four epilepsy patients.

Result: There were cognitive function decreased in recalling 47,1% and 26,5% in Attention and calculation. The relationship between the frequency of seizure (p = 0.028) and therapy (p = 0.012) on the  MMSE .

Conclusion: Politherapy was the dominant factor affecting the MMSE score of epilepsy patients.


  1. Fiest KM, Sauro KM, Wiebe S, Patten SB, Dykeman J, Pringsheim T, et al. Prevalence and incidence of epilepsy A systematic review and meta-analysis of international studies. 2016;
  2. World Health Organization. WHO | Epilepsy: a public health imperative [Internet]. Who. 2019. 171 p. Available from:
  3. Galtrey CM, Mula M, Cock HR. Stress and epilepsy: fact or fiction, and what can we do about it?. Pract Neurol. 2016;16(4):270-8.
  4. Lodhi S, Agrawal N. Neurocognitive problems in epilepsy. Adv Psychiatr Treat. 2012;18(3):232–40.
  5. Eddy CM, Rickards HE, Cavanna AE. The cognitive impact of antiepileptic drugs. Ther Adv Neurol Disord. 2011;4(6):385–407.
  6. Witt JA, Helmstaedter C. Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients. J Neurol. 2012;259(8):1727–31.
  7. Wijono AD. Influenced of related epilepsy factors to age and quality of life. Callosum Neurol. 2018;1(3):106–11.
  8. Lukas A, Harsono H, Astuti A. Cognitive impairment in eplipsy. Berk Ilm Kedokt Duta Wacana. 2016;1(2):144.
  9. Manado RDK, Sigar RJ, Kembuan MAHN, Mahama CN. Gambaran Fungsi Kognitif pada Pasien Epilepsi di Poliklinik Saraf; 2012.
  10. Arend J, Kegler A, Caprara ALF, Almeida C, Gabbi P, Pascotini ET, et al. Depressive, inflammatory, and metabolic factors associated with cognitive impairment in patients with epilepsy. Epilepsy Behav . 2018;86:49–57.
  11. Gebre AK, Haylay A. Sociodemographic, clinical variables, and quality of life in patients with epilepsy in Mekelle City, Northern Ethiopia. Behav Neurol. 2018;1-6.
  12. Sarhan EM, Walker MC, Selai C. Evidence for Efficacy of Combination of Antiepileptic Drugs in Treatment of Epilepsy. J Neurol Res. 2015;5(6):267–76.
  13. Lee JW, Dworetzky B. Rational polytherapy with antiepileptic drugs. Pharmaceuticals. 2010;3(8):2362–79.
  14. Shiozaki K, Kajihara S. Anti-epileptic drugs improved serial 7s scores on the Mini-Mental State Examination in elderly with cognitive impairment and epileptiform discharge on electroencephalography. Psychogeriatrics. 2019;19(1):38–45.
  15. Husna M, Kurniawan SN. Biomolecular Mechanism of Anti Epileptic Drugs. MNJ. 2018;(3):38–45.
  16. Goel D, Mittal M. Mono-Therapy versus Poly-Therapy: Ten Years Indian Experience on Various Seizure Disorders. World J Neurosci. 2015;05(05):350–7.

How to Cite

Lestari, N. D., Rizkidawati, R., Shafira, C. P., Suherman, S., & Mutiawati, E. (2020). Factors affecting the mini-mental state examination (MMSE) score in the epilepsy patients in Aceh, Indonesia. Bali Medical Journal, 9(1), 185–188.




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Nova Dian Lestari
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Rizkidawati Rizkidawati
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Cut Prita Shafira
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Suherman Suherman
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Endang Mutiawati
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