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Sclerosing lipogranuloma of the penis: a review of management and classification

  • Boyke Soebhali ,


Enlargement of penile girth is has always long been a subject of extensive debate and controversy. Genital injection of high-viscosity fluids like paraffin and mineral oil has been performed for more than 100 years. The debilitating effect has been long known, and the procedure has been abandoned by most medical practitioners. Injection often performed by non-professional persons or by the patients themselves, in a non-standardized way. The mineral oil contains foreign lipid that cannot be metabolized by human body, thus foreign body reaction will occur. The inflamed tissue and foreign body reaction will result in sclerosing lipogranuloma. This disorder also known with the injected materials names, e.g. paraffinoma, siliconoma or vaselinoma of the penis. Complications of the injection vary from inflammation, swelling, pain, hardened penile skin, to disastrous effects like ulcers, skin necrosis, pain in erection, sexual disability caused by pain either the patient or the sexual partner, and death by embolism. After injection of the mineral oil, in many patients the symptoms will occur almost instantly. Swelling, inflammation of the penile skin, redness, oedema (that will give an impression of larger penile girth) are among the symptoms occurred. Surgery is the best viable option to treat this disorder. Complete excision of the affected area, followed by covering the healthy area either by grafts or flaps. If available, scrotal skin is a good choice to cover the affected area. A good classification system of sclerosing lipogranuloma of the penis will be helpful in reporting and treating the disease.


  1. Shaeer O, Shaeer K. Delayed Complications of Gel Injection for Penile Girth Augmentation. J Sex Med. 2009;6(7):2072–8.
  2. Inn FX, Imran F-H, Ali MF, IH R. Penile augmentation with resultant foreign material granuloma and sequalae. Malays J Med Sci MJMS. 2012;19(4):81-88.
  3. Hohaus K, Bley B, Köstler E, Schönlebe J, Wollina U. Mineral oil granuloma of the penis. J Eur Acad Dermatol Venereol. 2003;17(5):585–587.
  4. Rosecker Ã, Bordás N, Pajor L, Bajory Z. Hungarian “Jailhouse Rockâ€: Incidence and Morbidity of Vaseline Selfâ€Injection of the Penis. J Sex Med. 2013;10(2):509–15.
  5. Pónyai K, Marschalkó M, Hársing J, Ostorházy E, Kelemen Z, Nyirády P, et al. Paraffinoma. JDDG J Dtsch Dermatol Ges. 2010;8(9):686–8.
  6. Foxton G, Vinciullo C, Tait CP, Sinniah R. Sclerosing lipogranuloma of the penis: Sclerosing lipogranuloma. Australas J Dermatol. 2011;52(3):e12–4.
  7. Akkus E, Iscimen A, Tasli L, Hattat H. Paraffinoma and Ulcer of the External Genitalia after Selfâ€Injection of Vaseline. J Sex Med. 2006;3(1):170–2.
  8. Fakin R, Zimmermann S, Jindarak S, Lindenblatt N, Giovanoli P, Suwajo P. Reconstruction of Penile Shaft Defects Following Silicone Injection by Bipedicled Anterior Scrotal Flap. J Urol. 2017;197(4):1166–70.
  9. Bjurlin MA, Carlsen J, Grevious M, Jordan MD, Taylor A, Divakaruni N, et al. Mineral Oil-induced Sclerosing Lipogranuloma of the Penis. 2010;3(9):4-9.
  10. Nyirády P, Kelemen Z, Kiss A, Bánfi G, Borka K, Romics I. Treatment and Outcome of Vaseline-Induced Sclerosing Lipogranuloma of the Penis. Urology. 2008;71(6):1132–7.
  11. Arthaud JB. Silicone-Induced Penile Sclerosing Lipogranuloma. J Urol. 1973;110(2):210-16.
  12. Bradley Jr RH, Ehrgott WA. Paraffinoma of the penis: case report. J Urol. 1951;65(03):453–9.
  13. Pehlivanov G, Kavaklieva S, Kazandjieva J, Kapnilov D, Tsankov N. Foreign-body granuloma of the penis in sexually active individuals (penile paraffinoma). J Eur Acad Dermatol Venereol. 2008;22(7):845–51.
  14. Rosenberg E, Romanowsky I, Asali M, Kaneti J. Three Cases of Penile Paraffinoma: A Conservative Approach. Urology. 2007;70(2):372.e9-372.e10.
  15. Dillon BE, Chama NB, Honig SC. Penile size and penile enlargement surgery: a review. Int J Impot Res. 2008;20(6):519–29.
  16. Vardi Y, Lowenstein L. Penile enlargement surgery—fact or illusion? Nat Clin Pract Urol. 2005;2(3):114–5.
  17. Kadouch JA, van Rozelaar L, Kanhai RJC, Sawor JH, Karim RB. Complications of Penis or Scrotum Enlargement Due to Injections with Permanent Filling Substances: Dermatol Surg. 2012;38(7pt2):1244–50.
  18. Wylie KR, Eardley I. Penile size and the ?small penis syndrome? BJU Int. 2007;99(6):1449–55.
  19. Bayraktar N, Başar İ. Penile Paraffinoma. Case Rep Urol. 2012;2012:1–2.
  20. Santos P, Chaveiro A, Nunes G, Fonseca J, Cardoso J. Penile paraffinoma. J Eur Acad Dermatol Venereol. 2003;17(5):583–584.
  21. Turner B, Goldstraw E, Pati J. Penile paraffinoma. Int J Urol Nurs. 2013;7(1):53–56.
  22. Sejben I, Rácz A, Svébis M, Patyi M, Cserni G. Petroleum jelly-induced penile paraffinoma with inguinal lymphadenitis mimicking incarcerated inguinal hernia. Can Urol Assoc J. 2012;6(4):E137.
  23. Casavantes L, Lemperle G, Morales P. Penile Girth Enhancement With Polymethylmethacrylate-Based Soft Tissue Fillers. J Sex Med. 2016;13(9):1414–22.
  24. Silberstein J, Downs T, Goldstein I. Penile Injection with Silicone: Case Report and Review of the Literature. J Sex Med. 2008;5(9):2231–7.
  25. Arduino L. Sclerosing Lipogranuloma of Male Genitalia. J Urol. 1959;82(1):155–61.
  26. Steffens J, Kosharskyy B, Hiebl R, Schönberger B, Röttger P, Loening S. Paraffinoma of the external genitalia after autoinjection of vaseline. Eur Urol. 2000;38(6):778–781.
  27. Manny T, Pettus J, Hemal A, Marks M, Mirzazadeh M. Penile Sclerosing Lipogranulomas and Disfigurement from Use of “Super Extenze†among Laotian Immigrants. J Sex Med. 2011;8(12):3505–10.
  28. Zalar Jr JA, Knode RE, Mir JA. Lipogranuloma of the penis. J Urol. 1969;102(1):75–77.
  29. Lee T, Choi HR, Lee YT, Lee YH. Paraffinoma of the penis. Yonsei Med J. 1994;35(3):344–8.
  30. Cohen JL, Keoleian CM, Krull EA. Penile paraffinoma: Self-injection with mineral oil. J Am Acad Dermatol. 2002;47(5):S251–3.
  31. Eandi JA, Yao AP, Javidan J. Penile paraffinoma: the delayed presentation. Int Urol Nephrol. 2007;39(2):553–5.
  32. Choudhury N, Frame JD, Lewi HJE. Penile paraffinoma and a novel treatment. BJU Int. 2003;92(s3):e14–e14.
  33. Shin YS, You JH, Choi H, Zhang LT, Zhao C, Choi IS, et al. An unusual course after an injection of industrial silicone for penile augmentation. Can Urol Assoc J. 2015;11;9(3–4):145-151.

How to Cite

Soebhali, B. (2020). Sclerosing lipogranuloma of the penis: a review of management and classification. Bali Medical Journal, 9(1), 55–61.




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