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Correlation between verruca vulgaris and superoxide dismutase

  • Farica Amanda Fachri ,
  • Nelva K Jusuf ,
  • Imam B Putra ,


Abstract

Background: Verruca vulgaris is a form of benign tumors that infected epidermal cells caused by Human papillomavirus (HPV). In several studies states that imbalances in oxidant and antioxidant systems play an important role in HPV infection. SOD is a potent protective enzyme that selectively cleanses radicals of antioxidants by catalyzing dismutation to hydrogen peroxide.

Aim: The study aimed to determine the correlation between SOD level and verruca vulgaris.

Methods: This was an analytic study with a cross sectional design involving 35 subjects with verruca vulgaris and 35 healthy controls. Diagnosis of verruca vulgaris was made based on history and clinical examination. The authors conducted blood sampling and measurement of plasma SOD level to the patients and controls.

Results: The study found that the mean of SOD levels in verruca vulgaris patients were higher (49.27 ± 100.47 U/L) than controls (35.12 ± 50.44 U/L), but it didn’t find a correlation between verruca vulgaris and SOD with p = 0.511. The mean level of ≥ 6 months were higher (59.69 ± 140.85 U/L) than < 6 months (39.43 ± 36.09 U/L) with p = 0.369. The mean multiple lesion levels were higher (62.12 ± 140.76 U/L) than the SOD level of patients with a single lesion (37.14 ± 34.89 U/L) with p = 0.405. The mean of SOD levels of patients who had previously experienced verruca vulgaris was higher (72.79 ± 151.73 U/L) than those who had not it (31.63 ± 18.26 U/L) with p = 0.961.

Conclusion: We didn’t found a correlation between verruca vulgaris and SOD.

Keywords: verruca vulgaris HPV SOD

References

  1. Loo, S.K., and Yuk-ming Tang. Warts (non-genital). Clinical Evidence. 2009; 9:1–29.
  2. Cokluk, E., Sekeroglu, M.R., Aslan, M., Balahoroglu, R., Bilgili, S.G., Huyut, Z. Determining oxidant and antioxidant status in patients with genital warts. Redox Rep. 2015; 20 (5): 211–4.
  3. DOI: 10.1179/1351000215Y.0000000002
  4. Sasmaz, S., Arican, O., Kurutas, E.B. Oxidative stress in patients with nongenital warts. Mediators Inflamm. 2005; 4: 233–6. DOI: 10.1155/MI.2005.233
  5. Khondker, L., Shah, M., Khan, M. Verruca: Need to know about Human Papilloma Virus (HPV) infection. J Bangladesh Coll Physicians Surg. 2012 Jul; 30 (3): 151–8
  6. Syrjarnen, S. Current concepts on human papillomavirus infections in children. APMIS. 2010; 118: 494–509. DOI: 10.1111/j.1600-0463.2010.02620.x
  7. Rao, K.M.S., Naidu, V., Vinod, V.V.S. A clinical study on warts. J Clin Diagn Res. 2011; 5 (8): 1582–4.
  8. Kanelleas, A and Nicolaidou, E. Warts: Cutaneous and Anogenital. In: European Handbook of Dermatological Treatments. 3rd ed. Berlin Heidelberg: Springer-Verlag; 2015: p. 1053–61.
  9. James, W.D., Berger, T.G., Elston, D.M., Neuhaus, D.M. Viral Disease. In: Andrew’s Disease of the Skin Clinical Dermatology. 12th ed. Philadelphia: Elsevier; 2016. p. 359-417
  10. Maria das Graças Pereira, L., Porro, A.M., Gildo Francisco dos Santos, J., Tomimori, J. Human papillomavirus infection: etiopathogenesis, molecular biology, and clinical manifestations. An Bras Dermatol. 2011; 86: 306–17.
  11. Satyaprakash, A., and Mansur, C. Human Papillomaviruses. In: Mucocutaneous Manifestation of Viral Disease. 2nd ed. UK: Informa; 2010. p. 207–52.
  12. Fabbrocini, G., Cacciapuoti, S., Monfrecola, G. Human Papillomavirus Infection in Child. Open Dermatol J. 2009; 3: 111–6.
  13. Knight, J.A. Review: Free Radicals, antioxidant and the immune system. Ann Clin Lab Sci. 30 (2): 145–58.
  14. Reshi, M.L., Su, Y-C., Hong, J-R. RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol. 2014;1–16. DOI: 10.1155/2014/467452
  15. Finaud, J., Lac, G., Filaire, E. Oxidative stress relationship with exercise and training. Sports Med. 2006; 4 (36): 327–58.
  16. Mate´s J.M., Pe´rez-Gomez, C., Castro, I.N.N.D. Antioxidant enzymes and human diseases. Clin Biochem. 1999 Nov; 32(8): 595–603.
  17. Evans, P., and Halliwell, B. Micronutrients: oxidant/antioxidant status. British Journal of Nutrition. 2001; 85: S67-S74
  18. Birben, E., Sahiner, U.M., Sackesen, C., Ezzurum, S., Kalayci, O. Oxidative Stress and Antioxidant Defense.WAO Journal. 2012; 5: 9-19
  19. Arican, O., Ozturk, P., Kurutas, E.B., Unsal, V. Status of oxidative stress on lesional skin surface of plantar warts. J Eur Acad Dermatol Venereol. 2012; 1-5. DOI: 10.1111/j.1468-3083.2011.04419.x
  20. Reshi, M.L., Su, Y-C., Hong, J-R. RNA Viruses: ROS-Mediated Cell Death. Int J Cell Biol. 2014; 1–16. DOI: 10.1155/2014/467452
  21. Poli, G., Leonarduzzi, G., Biasi, F., Chiarpotto, E. Oxidative stress and cell signaling. Curr Med Chem. 2004; 11: 1163–82.
  22. Wardana, I.N.G., Widianti, I.G.A., Wirata, G. Testosterone increases corpus cavernous smooth muscle cells in oxidative stress-induced rodents (Sprague-Dawley). Bali Medical Journal. 2018;7(2):313-322. DOI:10.15562/bmj.v7i2.970
  23. Semrau, F., Ku¨hl R-J., Ritter, S., Ritter, K. Manganese Superoxide Dismutase (MnSOD) and Autoantibodies Against MnSOD in Acute Viral Infections. J Med Virol. 2010; 55: 161–7.

How to Cite

Fachri, F. A., Jusuf, N. K., & Putra, I. B. (2019). Correlation between verruca vulgaris and superoxide dismutase. Bali Medical Journal, 8(2), 505–508. https://doi.org/10.15562/bmj.v8i2.1441
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Farica Amanda Fachri
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Nelva K Jusuf
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Imam B Putra
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