Skip to main content Skip to main navigation menu Skip to site footer

The mucin 5AC level in medical faculty students with Computer Vision Syndrome (CVS)

Abstract

Introduction: Prolonged computer use will lead to a group of symptoms such as dryness of eyes, tired, headache and others called Computer Vision Syndrome (CVS). The decrease of Mucin 5 AC (MUC5AC) level could be one of the signs of dry eye disease on persons with CVS.

Objective: The purpose of this study is to describe the Mucin 5AC level in medical faculty students of Udayana University, Bali, Indonesia with CVS.

Method: It is an observational cross-sectional analytic study at Medical Faculty Udayana University on October 2018. Thirty four subject selected  by purposive sampling and examined with Schirmer I test, Tear Break Up time (TBUT) test, and Mucin 5AC test. All of the subject then divided into CVS group and non-CVS group. Mucin 5AC level which less than 186.33 ng/mL categorized as low mucin, while more than 186.33 ng/mL categorized as normal mucin level. Data was analyzed by crosstabulation table and chi-square test with significant value p < 0.05.

Result: Most of the students who diagnosed with CVS had lower mucin 5AC levels as much as 77,3% and 33,3% students with CVS had normal mucin 5AC level.  This study analyses found there is significant association between level of mucin 5AC with CVS. The students with low level of mucin 5AC had 6,8 higher risk tend to be CVS (OR=6,8; CI 95%= 1,42-32,37; p=0,012).

Conclusion: Low level of mucin 5AC has association with the risk of CVS in the medical students with prolonged computer use.

References

  1. Dota, A., Takaoka-Shichijo, Y. & Nakamura, M.. Gefarnate stimulates mucin-like glycoprotein secretion in conjunctival tissue and ameliorates corneal epithelial damage in animal dry-eye models. Clinical Ophthalmology (Auckland, N.Z.), 2013: 7; 211-7. Available at : https://www.dovepress.com/gefarnate-stimulate-mucin-like-glycoprotein-secretion-in-conjunctival-peer-reviewed-article-OPTH [Accessed May 5th, 2016].
  2. Tsubota, K., Tseng, S.C.G. & Nordlund, M.L. Anatomy and Physiology of the Ocular Surface. In Ocular Surface Disease Medical and Surgical Management. 2002: 3–15.
  3. Cantor, LB; Rapuano, CJ; Cioffi, G. Fundamentals and Principles of Ophthalmology. In 2016-2017 American Academy of Ophthalmology - Basic and Clinical Science Course, Section 2. 2016: 302–326.
  4. Davidson, H.J. & Kuonen, V.J. The Tear Film and Ocular Mucins. Veterinary Ophthalmology. 2004: 7(2); 71–77.
  5. Argüeso, P. et al. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren syndrome. Investigative Ophthalmology and Visual Science. 2002: 43(4); 1004–11.
  6. Floyd, A.M. et al. Mucin Deficiency Causes Functional and Structural Changes of the Ocular Surface. PLoS ONE. 2012: 7(12); 1–8.
  7. D ’souza, S. & Tong, L. Practical issues concerning tear protein assays in dry eye. 2014: 1–12.
  8. Paulsen, F. Functional anatomy and immunological interactions of ocular surface and adnexa. Developments in Ophthalmology. 2008: 41; 21–35.
  9. Ramamoorthy, P. & Nichols, J.J. Mucins in contact lens wear and dry eye conditions.Optometry and vision science : official publication of the American Academy of Optometry. 2008: 85(8); 631–642.
  10. Wigaeus Tornqvist E, Hagberg M, Hagman M, Hansson Risberg E, Toomingas A. The influence of working conditions and individual factors on the incidence of neck and upper limb symptoms among professional computer users. Int Arch Occup Env Health 2009; 82(6): 689-702.
  11. Bhanderi DJ, Choudhary S, Doshi VG. A community-based study of asthenopia in computer operators. Indian J Ophthalmol. 2008; 56 (January–February (1)):51–5.
  12. Uchino, M., Uchino Y., Dogru M., Kawashima M., Yokoi N., Komuro A., Sonomura Y., Kato H., Kinoshita S., Schaumberg DA., Tsubota K. Dry eye disease and work productivity loss in visual display users : The Osaka study. American Journal of Ophthalmology. 2014: 157(2): 294-300.
  13. Goto, E.,Savini, G., Prabhawasati, P., Kojima, T., Gruesterich, M., Espana, E. The Challenge of Dry Eye Diagnosis. Clinical Opthalmology. 2008; 2(1):31-55.
  14. Wolffsohn, J.S. et al. The Ocular Surface TFOS DEWS II Diagnostic Methodology report. Ocular Surface. 2017; 15(3): 539–574.
  15. Zhao, H. et al. Quantification of MUC5AC protein in human tears. Cornea. 2001; 20(8): 873– 877.
  16. Jumblatt, M.M. McKenzie, RW., Steele PS, Embert CG., Jumblatt JE. MUC7 expression in the human lacrimal gland and conjunctiva. Cornea. 2003; 22(1): 41-5. Available at : http://www.ncbi.nlm.nih.gov/pubmed/12502947 [Accessed June 12th, 2017].
  17. Gipson, I.K., Hori, Y. & Argüeso, P. Character of ocular surface mucins and their alteration in dry eye disease. The ocular surface. 2014; 2(2): 131-148.

How to Cite

Juliari, I. G. A. M., Sari Dewi, R., Ratnasari, N. L. M. N., & Tri Handayani, A. (2019). The mucin 5AC level in medical faculty students with Computer Vision Syndrome (CVS). Bali Medical Journal, 8(2), 551–554. https://doi.org/10.15562/bmj.v8i2.1425

HTML
3

Total
2

Share

Search Panel

I Gusti Ayu Made Juliari
Google Scholar
Pubmed
BMJ Journal


Ratna Sari Dewi
Google Scholar
Pubmed
BMJ Journal


Ni Luh Made Novi Ratnasari
Google Scholar
Pubmed
BMJ Journal


Ariesanti Tri Handayani
Google Scholar
Pubmed
BMJ Journal