Skip to main content Skip to main navigation menu Skip to site footer

Relationship of Plasma Cystatin C level and renal dysfunction in patients with preeclampsia

  • Makmur Sitepu ,
  • Azano Sitepu ,
  • Johny Marpaung ,
  • Dudy Aldiansyah ,
  • Edy Ardiansyah ,
  • Deri Edianto ,
  • Khairani Sukatendel ,


Background: Renal dysfunction is an important aspect of the pathophysiology of preeclampsia besides vascular endothelial dysfunction and placental hypoperfusion. Cystatin C is one of the most important inhibitors of extracellular protease enzymes and can be reliable marker for the calculation of Glomerular Filtration Rates (GFR). This study aimed to determine the relationship between plasma levels of cystatin C and renal dysfunction in patients with preeclampsia.

Method: This was an analytical cross sectional study conducted at Haji Adam Malik General Hospital Medan, Dr. Pirngadi Hospital Medan, several affiliated hospitals of the Faculty of Medicine University of North Sumatra and Prodia Clinical Laboratory Medan. A total of 26 preeclamptic patients were included in this study. Samples were divided into renal dysfunction and without renal dysfunction group.

Results: Eleven subjects with renal dysfunctions were mostly aged 20 – 35 years (73.3%), and the other eight subjects without renal dysfunctions were at the age of 20 – 35 years (72.7%). Most of the subjects had multigravida pregnancies, five subjects (33.3%) with renal dysfunctions, and six subjects (54.5%) without renal dysfunctions. The mean level of cystatin C in renal dysfunction (1.52 ± 0.37 mg/L) was significantly higher than without renal dysfunction (1.17 ± 0.12 mg/L) (p < 0.05).

Conclusion: The cystatin C level in preeclamptic patients with renal dysfunctions patient was higher than those who did not have renal dysfunction.


  1. World Health Statistics, WHO: Child Birth Of Pregnant Women, WHO 1-2. 2016
  2. Isasari KM, Pangemanan WT, Zulqarnain I, Kemas R. High plasma cystatin C in women with severe preeclampsia. Indones J Obstet Gynecol. 2014; 2(1): 22 – 7.
  3. Wulan SK. Characteristics of Preeclamptic Patients and Eclampsia at Haji Adam Malik Hospital 2009-2011. Medan: Departement of Obstetric and Gynecology Faculty of Medicine University of North Sumatera; 2012.
  4. Yusrawati, Rinaldy A, Bachtiar H. Difference between the mean serum cystatin C between maternal severe preeclampsia with normal pregnancy. Majalah Obgin Emas. 2015; 2(19): 1 – 8.
  5. Kristensen K, Larsson I, Hansson SR. Increased cystatin C expression in the pre-eclamptic placenta. Mol Hum Reprod. 2007; 13(3): 189 – 95. DOI: 10.1093/molehr/gal111.
  6. Franceschini N, Qiu C, Barrow DA, Williams MA. Cystatin C and preeclampsia: a case control study. Ren Fail. 2008; 30(1): 89 – 95. DOI: 10.1080/08860220701742229.

How to Cite

Sitepu, M., Sitepu, A., Marpaung, J., Aldiansyah, D., Ardiansyah, E., Edianto, D., & Sukatendel, K. (2019). Relationship of Plasma Cystatin C level and renal dysfunction in patients with preeclampsia. Bali Medical Journal, 8(2), 611–612.