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Mutation of the Fas-promoter-670 gene, AA to GA in the normal cervix-epithelial-cells of high risk Indonesian mother: A case report


Background: Normalities of the cervix-epithelial-cells (CEC) can be determined base on the cell morphology and their nucleus. If one of the cervix-epithelial-cells has gene mutations, it will form mutant clones, further growing, developing and malignant. The Fas-promoter-670 gene is allegedly associated with cervical cancer.

Case Presentation: A  30-year-old  of high-risk Indonesian mother,  has two children, on April 21th  2016 has followed Pap smear examination with thin prep method. Subjects, in this case, had normal cervix-epithelial-cells. Characteristics of the cervix-epithelial-cells include cell biometrics among others cell length, cell width, cell area, cell perimeter, nucleus area, and nucleus perimeter. Fas-promoter-670 genotype in the lymphocytes-cells is AA (normal= wild type), whereas in the cervix-epithelial-cells is GA (heterozygous mutant).

Conclusion: Based on characteristic of cell biometrics, cervix-epithelial-cells in high-risk Indonesian mother is normal. The genotype of the Fas-promoter-670 gene in the lymphocyte cells is AA, whereas in the cervix-epithelial-cells has mutation to GA.


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How to Cite

Parwanto, M. L. E., Wratsangka, R., Guyansyah, A., & Anggraeni, K. (2019). Mutation of the Fas-promoter-670 gene, AA to GA in the normal cervix-epithelial-cells of high risk Indonesian mother: A case report. Bali Medical Journal, 8(1), 360–364.




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