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Genetic polymorphism in CYP1A1 affected susceptibility to acne vulgaris in Pekanbaru Indonesian Population, Desember 2013 - Maret 2014


Background: Susceptibility to acne vulgaris had seen by modulating devolution of encoding cytochrome P450 1A1 (CYP1A1) gene polymorphism which is involved in bioactivation and detoxification of drugs, chemical agents, and pollutants from the environment. Acne incidence is known different based on ethnic, so that, we did this study in Indonesian acne vulgaris patients.

Aim: To characterize cytochrome P450 1A1 (CYP1A1) polymorphism in Indonesian acne vulgaris patients.

Method: Multiplex polymerase chain reaction (PCR) dan PCR based restriction fragment length polymorphism (PCR-RFLP) were used to detect polymorphism changes of CYP1A1 by doing a case-control study of 35 acne patients dan 35 controls. All the examination samples were obtained from Pekanbaru, Riau Province, Indonesia.

Result: The frequency of CYP1A1 heterozygous variant alleles was higher in case (odds ratio 2.21; 95% Confidence Interval 0.71-6.87).

Conclusion: Polymorphism of CYP1A1 allele m1 gene increases susceptibility to acne vulgaris.


  1. Cunliffe WJ, 1989. Natural history of acne. In acne London: Martin Dunitz Ltd, pp 2 – 10
  2. William HC, Dellavalle RP, Garner S. 2012. Acne Vulgaris Lancet 379 : 361 – 372
  3. Wasitaatmadja SM. 2010. Pemahaman dan Penatalaksanaan Acne. National Symposium & Workshop in Cosmetic Dermatology pp 1 – 16
  4. Nelson DR, Kamataki T, Waxman DJ, Guen gerich FP, Coon MJ, Gunsalus IC, Gotoh O, Okuda K, Nebert DW: The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 1993;12:1-51
  5. Nelson DR, 1995. P450 superfamily: update of new segmen, gene mapping, accession numbers and nomenclature pharmacogenetic, 6; 1-42
  6. Nebert DW, Puga A, Vailiou V. 1993. Role of the Ah receptor and the dioxin-inducible (Ah) gen battery in toxicity, cancer and signaling transduction. Ann. Ny acad. Sci 685; 624-640
  7. Gotoh, O., and Fujii-Kuriyama, Y. (1989) Evolution, structure, and gene regulation of cytochrome P450, In Frontier in Biotrans-formation (Ruckpaul, K., and Rein, H., eds) Vol. I, pp. 195-243, Akademie Verlag, Berlin
  8. Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watanabe K (1990). Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P-450 1A1 gene. FEBS. Lett. 263:131-133
  9. Vecchini F, Lenoir-Viale MC, Cathelineau C, Magdalou J, Bernard BA, Shroot B: Presence of a retinoid responsive element in the promoter region of the human cytochrome P4501A1 gene. Biochem Biophys Res Commun 1994;201:1205-1212
  10. Morgan ET, 2001. Minireview regulation of cytochrome P450 by inflammatory mediators: why and how. Department of Pharmocology, Emory University School of Medicine, Atlanta, Georgia. The American Society for Pharmacology and Experimental Therapeutics; DMD 29; 207-212
  11. Zouboulis ChC, Korge B, Mischke D, Orfanos CE: Altered proliferation, synthetic activity, and differentiation of cultured human sebocytes in the absences of vitamin A and their modulation by synthetic retinoids. J Invest Dermatol 1993;101:628-633
  12. Duester G (1996) Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry 35:12221-12227
  13. Zhang QY, Dunbar D, Kaminsky L: Human Cytochrome P-450 Metabolism of Retinal to Retinois Acid. Drug Metabolism and dispotition. The American Society for Pharmacology and Experimental Therapeutic, 1999; 28; 292-7
  14. Zouboulis ChC, Korge B, Akamatsu H, Xia L, Schiller S, Gollnick H, Orfanos CE: Effects of 13-cis-retinoic acid, all-trans-retinoic acid and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. J Invest Dermatol 1991;96:792-797
  15. Pei CT, Weuya H, Yeu CL, Shih H, Yueliang LG. 2006. Genetic polymorfisme in CYP1A1 and GSTMI predispose humans to PCBs/PCDFs-induced skin lesions. J Chemosphere, 63; 1410-1418
  16. Paraskevaidis A, Prakoulis N,Roots I, Orfanos C.E, Zoubulis CC. Polymorphism in the Human Cytochrome P-450 1A1 Gen (CYP1A1) as a Factor for Devoloping Acne. Dermatology, 196 : 171 – 175
  17. Shimada T, Martin MV, Pruess Schwartz D, Marnett LJ, Guengerich FP (1989). Roles of Individual cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a) pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res. 49: 6304-6312
  18. Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fuji-Kuriyama Y: Structure and Drug Inducibility of human Cytochrome P-450 Gene. Eur J Biochem 1986; 159:219-225
  19. Landi, M.T., Bertazzi, P.A., Shields, P.G., Clark, G., Lucier, G.W., Garte, S.J., Cosma, G., Caporaso, N.E., 1994. Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics 4; 242-246
  20. Spur NK, Gough AC, Stevenson K, Wolf CR: MspI-polymorphism detected with a cDNA probe for the P-450 I family on chromosome 15. Nucleic Acids Res 1987;15:5901
  21. Marchand A, Barouki R, Garlatti M. Regulation of NAD(P)H:quinine oxidoreductase 1 gene expression by CYP1A1 activity. Mol Pharmacol 2004;65;1029-1037
  22. Garte S, Boffetta P, Caporaso N, Vineis P (2001) Metabolie gene allele nomenclature. Cancer Epidomiol Biomarkers Prev 10:1305-1306
  23. Duell E, Astrom A, Griffiths CEM, Chambon P, Voorhees J:Retinoic acid therapy of human skin in vivo stimulates cytochrome P-450 mediated transformation of retinoic acid, which increase retinoic acid receptor dependent reporter gene transcription in vitro. J Invest Dermatol 1991;96:533
  24. Gollnick H, Cunliffe WJ. Management of acne, a report from a global alliance to improve outcomes in acne. J Am Acad Dermatol 2003;49:1-37

How to Cite

Darmani, E., Darwin, E., Damayanti, I., & Nurdin, A. E. (2019). Genetic polymorphism in CYP1A1 affected susceptibility to acne vulgaris in Pekanbaru Indonesian Population, Desember 2013 - Maret 2014. Bali Medical Journal, 8(1), 169–172.




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