Background: Vitiligo is an idiopathic, acquired pigmentation disorder of skin and mucosa, with clinical manifestations of Â milky white patches. To these days, the underlying pathogenesis of vitiligo is still unknown. Four hypothesis that mostly described are genetic, autoimmune, neural and biochemistry. The biochemistry hypothesis is associated with oxidative stress and antioxidants. Superoxide dismutase (SOD) is a first line antioxidant defense mechanism that plays a role in converting radical superoxide (O2-) to hydrogen peroxide (H2O2). The accumulation of H2O2 if it continues to accumulate can cause melanocyte death.
Aim : To determine SOD level profile in vitiligo patients in H. Adam Malik general hospital Medan
Subject and method: This was a cross-sectional descriptive study which involved 26 vitiligo patients that were diagnosed by clinical and Woodâ€™s lamp examinations. We conducted blood sampling and measurement of SOD level to the patients, the results obtained are presented in tabulation form.
Results: In this study, mean of SOD level was 110,69Â±167,50 ng/ml. When compared based on characteristics, we got mean of SOD level was higher in female group (130,23Â±182,35 ng/ml). The highest SOD level we found in 56-65 years old group (191,90Â±270,15 ng/ml), duration of disease 11-15 years group (191,17Â±267,21 ng/ml) and nonsegmental group (113,98Â±170,10 ng/ml).
Conclusion: Mean SOD levels in vitiligo patients was 110,69 ng/ml. SOD level were found in female higher than male, highest in age 56-65 years old group and duration of disease 11-15 years, in vitiligo nonsegmental type higher than segmental type.