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Superoxide dismutase level profile in vitiligo patients at H. Adam Malik General Hospital Medan

  • Kharina Y Putri ,
  • Nelva K Jusuf ,
  • Kamaliah Muis ,


Abstract

Background: Vitiligo is an idiopathic, acquired pigmentation disorder of skin and mucosa, with clinical manifestations of  milky white patches. To these days, the underlying pathogenesis of vitiligo is still unknown. Four hypothesis that mostly described are genetic, autoimmune, neural and biochemistry. The biochemistry hypothesis is associated with oxidative stress and antioxidants. Superoxide dismutase (SOD) is a first line antioxidant defense mechanism that plays a role in converting radical superoxide (O2-) to hydrogen peroxide (H2O2). The accumulation of H2O2 if it continues to accumulate can cause melanocyte death.

Aim : To determine SOD level profile in vitiligo patients in H. Adam Malik general hospital Medan

Subject and method: This was a cross-sectional descriptive study which involved 26 vitiligo patients that were diagnosed by clinical and Wood’s lamp examinations. We conducted blood sampling and measurement of SOD level to the patients, the results obtained are presented in tabulation form.

Results: In this study, mean of SOD level was 110,69±167,50 ng/ml. When compared based on characteristics, we got mean of SOD level was higher in female group (130,23±182,35 ng/ml). The highest SOD level we found in 56-65 years old group (191,90±270,15 ng/ml), duration of disease 11-15 years group (191,17±267,21 ng/ml) and nonsegmental group (113,98±170,10 ng/ml).

Conclusion: Mean SOD levels in vitiligo patients was 110,69 ng/ml. SOD level were found in female higher than male, highest in age 56-65 years old group and duration of disease 11-15 years, in vitiligo nonsegmental type higher than segmental type.

Keywords: vitiligo SOD antioxidant

References

  1. Tarlé RG, Nascimento LM, Mira MT, Castro CC. Vitiligo--part 1. An Bras Dermatol. 2014 May-Jun;89(3):461-70. doi: 10.1590/abd1806-4841.20142573
  2. Jusuf NK. Pattern of pigmentation disorder in Cosmetic Dermatology Clinic H. Adam Malik General Hospital, Medan, 2012 – 2015. Journal of General-Procedural Dermatology & Venereology Indonesia 2 (1), 1-6, 2017. doi: 10.19100/jdvi.v2i1.46
  3. Kamel N, Sobhy N, Kamal H, Ismail M. A comparative study of oxidant-antioxidant status in blood and tissue in vitiligo patients. EDOJ [Internet].2010 [cited 2015 Oct 1] ; 6(2): 1-10. Available from: http://www.edoj.org.eg/vol006/0602/002/paper.pdf
  4. Baum S, Barzilai A, Trau H. Vitiligo. In : Shoenfeld Y, Cervera R, Gershwin ME, editors. Diagnostic criteria in autoimmune diseases. press [Internet]. 2008 [cited 2015 Oct 01].p. 353-8. doi: 10.1007/978-1-60327-285-8
  5. Le Quéré S, Lacan D, Lemaire B, Carillon J, Schmitt K. The role of superoxide dismutase (SOD) in skin disorders A review. Nutrafoods (2014) 13:13-27. doi: 10.1007/s13749-014-0001-x
  6. Shi MH, Wu Y, Li L, Cai YF, Liu M, Gao XH, et al. Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde. Clin Exp Dermatol. 2017 Jan;42(1):21-29. doi: 10.1111/ced.12950
  7. Sravani PV, Babu NK, Gopal KV, Rao GR, Rao AR, Moorthy B, Rao TR. Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin. Indian J Dermatol Venereol Leprol Dermatol 2009;75:268-71. doi: 10.4103/0378-6323.48427
  8. Rahmayanti ND, Rahmadewi. Studi Retrospektif: Profil Pasien Baru Vitiligo (A Retrospective Study: The Profile of New Patient with Vitiligo). Berkala Ilmu Kesehatan Kulit dan Kelamin – Periodical of Dermatology and Venereology. 2016 Aug; 28(2):52-8. doi: 10.20473/bikkk.V28.2.2016.52-58
  9. Agrawal D, Shajil EM, Marfatia YS, Begum R. Study on the antioxidant status of vitiligo patients of different age groups in Baroda. Pigment Cell Res. 2004 Jun;17(3):289-94. doi: 10.1111/j.1600-0749.2004.00149.x
  10. Arican O, Kurutas EB. Oxidative stress in the blood of patients with active localized vitiligo. Acta Dermatovenerol Alp Pannonica Adriat. 2008 Mar;17(1):12-6
  11. Junqueira VB, Barros SB, Chan SS, Rodrigues L, Giavarotti L, Abud RL. Aging and oxidative stress. Mol Aspects Med. 2004 Feb-Apr;25(1-2):5-16. doi: 10.1016/j.mam.2004.02.003
  12. Shajil EM, Begum R. Antioxidant status of segmental and non-segmental vitiligo. Pigment Cell Res. 2006 Apr;19(2):179-80. doi: 10.1111/j.1600-0749.2006.00299.x

How to Cite

Putri, K. Y., Jusuf, N. K., & Muis, K. (2018). Superoxide dismutase level profile in vitiligo patients at H. Adam Malik General Hospital Medan. Bali Medical Journal, 7(3). https://doi.org/10.15562/bmj.v7i3.1079
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Kharina Y Putri
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Nelva K Jusuf
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Kamaliah Muis
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