Background: Geriatric patients are elderly patients who have memory impairment problems, which may have an impact on medication adherence. The aim of this study was to evaluate the effect of medicine reminder on the smartphone to increase the adherence of geriatric patients with type 2 diabetes mellitus. Method: This study used the Randomized Control Trial (RCT) method, where the subjects were divided into 2 groups: geriatric patients who were performing diabetic neuropathic pain therapy with the help of the Medicine Reminder (Group of Intervention) and without the aid of Medicine Reminder (Usual Care) Which are randomized using odd-even techniques. Patient therapy compliance is assessed by pill count. Results: Subjects who received medicine reminder intervention had significantly greater adherence than the control group (p <0.05). The RR value obtained is 2.38 with CI95% at intervals of 1.58-3.61. Conclusions: The medicine reminder application can improve geriatric patient therapy adherence with significant diabetic neuropathic pain.