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A preliminary study of the effect of PPAR- γ agonist from Myristica fragrans houtt seed extract on the biogenesis of rat infant’s brain mitochondria and D1 dopamine receptor



Abstract

Background: Myristica fragrans (nutmeg) seed extract (NuSE) has been reported as a ligand for Peroxisome Proliferator-Activated Receptor (PPAR)-γ due to hypoglycemic and antidiabetic effects. The recent study also finds the role of PGC-1α as the regulator of mitochondrial biogenesis and the co-activator of PPAR-γ as well. Dopamine 1 receptor (D1DR) is generally distributed in the brain with a various function, such as cognitive function. As a preliminary study, we explore a possibility the current knowledge of the mechanism of NuSE enhance dopamine 1 receptor via neuronal mitochondrial biogenesis on infant rat brain tissue. Aim: This study was aimed to investigate whether PPAR- γ agonist from NuSE can induce expression brain PGC-1α and D1DR (D1A and D1B). Methods: Seven male rats (4 weeks) as a control and another seven male rats (4 weeks) was giving 8.1 mg NuSE /day by gavage within 12 weeks. End of the day, the rats were sacrificed, and the forebrain was extraction. Expression mRNA PGC 1-α and DIDR  were analyzed. Results: The result showed significantly higher relatives expression of mRNA PGC-1α and mRNA D1DR in NuSE group (p<0.05). Conclusion: The findings provide preliminary support that PPAR-γ agonist from NuSE may offer a novel for the study brain mitochondrial biogenesis related mechanism of signaling dopamine receptor.

 

Keywords: PPAR-γ agonist PGC-1α D1DR brain mitochondrial biogenesis

References

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How to Cite

Veronica, F., Lubis, L., S, A., Fitri, L. L., Rizal, A., P, A., Gunawan, H., Lesmana, R., Dandan, K. L., & Supratman, U. (2018). A preliminary study of the effect of PPAR- γ agonist from Myristica fragrans houtt seed extract on the biogenesis of rat infant’s brain mitochondria and D1 dopamine receptor. Bali Medical Journal, 7(3). https://doi.org/10.15562/bmj.v7i3.1027
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